In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1.

Details

Serval ID
serval:BIB_DA401F1E2D12
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Kieffer N., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
07/2017
Peer-reviewed
Oui
Volume
61
Number
7
Pages
10.1128
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The plasmid-mediated javax.xml.bind.JAXBElement@4ad6613a gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The javax.xml.bind.JAXBElement@2b02fe97 gene is associated with insertion sequence IS javax.xml.bind.JAXBElement@34ae85e7 (IS javax.xml.bind.JAXBElement@618d2e82 family). javax.xml.bind.JAXBElement@182b4c38 mobilization assays demonstrated the functionality of the composite transposon structure IS javax.xml.bind.JAXBElement@2461ffec -IS javax.xml.bind.JAXBElement@6420d73a Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the javax.xml.bind.JAXBElement@6cd11c02 gene by transposition.

Keywords
Anti-Bacterial Agents/pharmacology, Colistin/pharmacology, DNA Transposable Elements/genetics, Drug Resistance, Bacterial/genetics, Gene Duplication/drug effects, Gene Duplication/genetics, Microbial Sensitivity Tests, Plasmids/genetics, Polymyxins/pharmacology, Sequence Analysis, DNA, ISApl1, composite transposon, mcr-1, plasmid, polymyxins, transposition
Pubmed
Web of science
Open Access
Yes
Create date
17/09/2017 15:29
Last modification date
20/08/2019 15:59
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