Peroxisome proliferator-activated receptor β/δ: a master regulator of metabolic pathways in skeletal muscle.

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Serval ID
serval:BIB_DA36A39A4D6E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptor β/δ: a master regulator of metabolic pathways in skeletal muscle.
Journal
Hormone molecular biology and clinical investigation
Author(s)
Lahiri S., Wahli W.
ISSN
1868-1883 (Print)
ISSN-L
1868-1883
Publication state
Published
Issued date
01/12/2010
Peer-reviewed
Oui
Volume
4
Number
2
Pages
565-573
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Skeletal muscle is considered to be a major site of energy expenditure and thus is important in regulating events affecting metabolic disorders. Over the years, both in vitro and in vivo approaches have established the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in fatty acid metabolism and energy expenditure in skeletal muscles. Pharmacological activation of PPARβ/δ by specific ligands regulates the expression of genes involved in lipid use, triglyceride hydrolysis, fatty acid oxidation, energy expenditure, and lipid efflux in muscles, in turn resulting in decreased body fat mass and enhanced insulin sensitivity. Both the lipid-lowering and the anti-diabetic effects exerted by the induction of PPARβ/δ result in the amelioration of symptoms of metabolic disorders. This review summarizes the action of PPARβ/δ activation in energy metabolism in skeletal muscles and also highlights the unexplored pathways in which it might have potential effects in the context of muscular disorders. Numerous preclinical studies have identified PPARβ/δ as a probable potential target for therapeutic interventions. Although PPARβ/δ agonists have not yet reached the market, several are presently being investigated in clinical trials.

Keywords
fatty acid oxidation, lipid metabolism, muscle fiber switching, obesity, peroxisome proliferator-activated receptor-β/δ, (PPARβ/δ)
Pubmed
Open Access
Yes
Create date
23/05/2011 11:19
Last modification date
01/10/2019 6:19
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