Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse.

Details

Serval ID
serval:BIB_DA3404F17420
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse.
Journal
European Journal of Clinical Pharmacology
Author(s)
Kintz P., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0031-6970[print], 0031-6970[linking]
Publication state
Published
Issued date
1989
Volume
37
Number
5
Pages
531-532
Language
english
Abstract
A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using levallorphan as the internal standard. After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring.
Keywords
Acetylation, Gas Chromatography-Mass Spectrometry, Heroin Dependence/urine, Humans, Morphine Derivatives/urine, Street Drugs/analysis
Pubmed
Create date
15/10/2010 13:01
Last modification date
20/08/2019 15:59
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