Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients.

Details

Serval ID
serval:BIB_DA1DBEFAB0B0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients.
Journal
Chirality
Author(s)
Eap C.B., Powell K., Campus-Souche D., Monney C., Baettig D., Taeschner W., Baumann P.
ISSN
0899-0042 (Print)
ISSN-L
0899-0042
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
6
Number
7
Pages
555-563
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
An HPLC method is presented which allows the measurement in the same run of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in plasma and urine of mianserin-treated patients. Limits of quantitation for the (S)- and (R)-enantiomers of mianserin and desmethylmianserin were 4 and 2.5 ng/ml, respectively, in plasma, and for the (S)- and (R)-enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin 5, 2.5, and 5 ng/ml, respectively, in urine. The measured ratios of (S)-mianserin/(R)-mianserin and (S)-desmethylmianserin/(R)-desmethylmianserin in the plasmas of 10 mianserin-treated patients, all extensive metabolizers of debrisoquine as determined by CYP2D6 genotyping, varied, respectively, from 1.0 to 4.06 and from 0.19 to 0.64. As the enantiomers of mianserin differ in their pharmacological profile, these results could partially explain why, until now, no consistent relationship has been established between the therapeutic response and total [(S) + (R)] plasma levels of this antidepressant.
Keywords
Adult, Aged, Aged, 80 and over, Chromatography, High Pressure Liquid/methods, Female, Genotype, Humans, Male, Mianserin/analogs & derivatives, Mianserin/blood, Middle Aged, Polymerase Chain Reaction, Stereoisomerism
Pubmed
Web of science
Create date
01/03/2013 10:29
Last modification date
20/08/2019 15:59
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