PURPOSE: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an acquired inflammatory disorder affecting the retina, retinal pigment epithelium, and choroid of healthy adults. APMPPE has been reported to occur after diverse infectious diseases, suggesting a possible immune disorder. The primary site of inflammation remains hypothetical. METHODS/RESULTS: A previously healthy 37-year-old patient developed APMPPE soon after the onset of mumps. Indocyanine green angiography (ICGA) revealed numerous hypofluorescent lesions throughout the posterior pole, outnumbering the lesions detectable either ophthalmoscopically or on fluorescein angiography. The hypofluorescent lesions visible on ICGA disappeared on follow-up studies. CONCLUSION: This case represents the first reported patient with AMPPE following mumps. Our results suggest that a multifocal choroidopathy might be the underlying cause of APMPPE.