Recent advances in blood-related proteomics

Details

Serval ID
serval:BIB_D9B440C4A865
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent advances in blood-related proteomics
Journal
Proteomics
Author(s)
Thadikkaran  L., Siegenthaler  M. A., Crettaz  D., Queloz  P. A., Schneider  P., Tissot  J. D.
ISSN
1615-9853 (Print)
Publication state
Published
Issued date
08/2005
Volume
5
Number
12
Pages
3019-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Abstract
Blood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has permitted the development of prognostic and diagnostic indicators for disease. The recent advance in MS and protein separation now allows similar progress in the analysis of proteins. Proteomics offers great promise for the study of proteins in plasma/serum, indeed a number of proteomics databases for plasma/serum have been established. This is a very complex body fluid containing lipids, carbohydrates, amino acids, vitamins, nucleic acids, hormones, and proteins. About 1500 different proteins have recently been identified, and a number of potential new markers of diseases have been characterized. Here, examples of the enormous promise of plasma/serum proteomic analysis for diagnostic/prognostic markers and information on disease mechanism are given. Within the blood are also a large number of different blood cell types that potentially hold similar information. Proteomics of red blood cells, until now, has not improved our knowledge of these cells, in contrast to the major progresses achieved while studying platelets and leukocytes. In the future, proteomics will change several aspects of hematology.
Keywords
Amyloid/chemistry Biological Markers Blood/*metabolism Blood Platelets/metabolism Cryoglobulins/chemistry Electrophoresis, Gel, Two-Dimensional Erythrocytes/cytology Hematology/methods Humans Leukemia/metabolism Leukocytes/cytology Protein Array Analysis Proteome Proteomics/*methods/trends
Pubmed
Web of science
Create date
25/01/2008 15:34
Last modification date
20/08/2019 15:59
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