Ex vivo evaluation of a new extracorporeal lung assist device: NovaLung membrane oxygenator.

Details

Serval ID
serval:BIB_D9B3176ECA5E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ex vivo evaluation of a new extracorporeal lung assist device: NovaLung membrane oxygenator.
Journal
The International Journal of Artificial Organs
Author(s)
Jegger D., Revelly J.P., Horisberger J., Mallabiabarrena I., Seigneul I., Jachertz M., Von Segesser L.K.
ISSN
0391-3988
Publication state
Published
Issued date
10/2005
Peer-reviewed
Oui
Volume
28
Number
10
Pages
985-999
Language
english
Notes
Publication types: Evaluation Studies ; Journal Article - Publication Status: ppublish
Abstract
When lung function is compromised,alternative devices need to be deployed in order to maintain blood oxygenation. A new device, NovaLung, has been designed for acute lung failure. We went about evaluating its gas exchange capability. Three calves (79.5 +/- 7.8 kg) were connected to the NovaLung System with a priming volume of 240 mL, gas exchange surface area of 1.3 m2 and exhibiting a biologically coated surface. A standard battery of blood samples were taken before implantation and over a six hour period. Hematocrit remained stable ranging from 27 +/- 4% (baseline) to 29 +/- 5% (6 hrs). Platelets were preserved ranging from 882 +/- 27.4 U/L (baseline) to 734 +/- 147 (6 hrs). LDH remained stable at 719 +/- 85 U/L (baseline) vs 686 +/- 190 U/L (6 hrs) and the pressure drop was maintained below 20 mmHg. Minimal hemolysis was observed. Oxygen transfer peaked at two hours acute extracorporeal lung support (ECLS)with a mean value of 130 +/- 50 ml/min. In conclusion, the device is easy to use,provides adequate O2 and CO2 transfer for partial lung support in an acute setting. Shows minimal signs of hemolysis and platelets levels are maintained throughout the six hour ECLS period.
Keywords
Animals, Blood Flow Velocity/physiology, Blood Pressure/physiology, Cattle, Equipment Design, Equipment Failure Analysis, Extracorporeal Membrane Oxygenation/instrumentation, Extracorporeal Membrane Oxygenation/methods, Hematocrit, Lung/blood supply, Lung Diseases/physiopathology, Lung Diseases/therapy, Oxygen/metabolism, Pulmonary Gas Exchange/physiology
Pubmed
Web of science
Create date
24/01/2008 18:03
Last modification date
20/08/2019 16:59
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