Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by (1)H magnetic resonance spectroscopy.

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State: Public
Version: author
Serval ID
serval:BIB_D9A268EF9C7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by (1)H magnetic resonance spectroscopy.
Journal
Neurobiology of Aging
Author(s)
Duarte J.M., Do K.Q., Gruetter R.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
35
Number
7
Pages
1660-1668
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum of C57BL/6 mice aged between 3 and 24 months . The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline. Interestingly, the neurochemical profile was different in male and female mice, particularly in the levels of taurine that may be under the control of estrogen receptors. These neurochemical profiles constitute the basal concentrations in cortex, hippocampus, and striatum of healthy aging male and female mice.
Pubmed
Web of science
Create date
11/04/2014 13:57
Last modification date
20/08/2019 15:58
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