Effects of cholinergic stimulation and antagonism on plasma insulin concentration in lean and obese human subjects

Details

Serval ID
serval:BIB_D975193674F1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of cholinergic stimulation and antagonism on plasma insulin concentration in lean and obese human subjects
Journal
Hormone and Metabolic Research
Author(s)
Tappy  L., Chiolero  R., Randin  J. P., Burckhardt  P., Felber  J. P.
ISSN
0018-5043 (Print)
Publication state
Published
Issued date
12/1986
Volume
18
Number
12
Pages
821-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
The effect of cholinomimetic stimulation by infusion of edrophonium chloride or muscarinic blockade by infusion of atropine sulfate on insulin and GIP secretion was studied in normal lean subjects during eu- and hyperglycemia. Cholinomimetic stimulation led to a slight non-significant increase and muscarinic blockade to a slight, non-significant suppression of both GIP and insulin. No modification of the insulin secretion pattern was observed under either condition during hyperglycemia. The effect of atropine infusion on fasting plasma insulin and GIP was subsequently studied in 11 obese patients and 10 lean subjects. Muscarinic antagonism by atropine led to a transient non-significant suppression of GIP and insulin in lean subjects, but to a significant, sustained suppression of these hormones in obese patients. Insulin and GIP levels were however, not suppressed to control values after atropine administration in obese patients. A positive correlation was found between fasting plasma insulin and maximal suppression of insulin attained during the 30 min following administration of atropine. It is concluded that part of the hyperinsulinemia observed in human obesity is under the control of the parasympathetic nervous system. An abnormal balance between sympathetic inhibitory and parasympathetic stimulatory tones on insulin secretion, as observed in the VMH lesioned rat, might be present in human obesity.
Keywords
Adult Atropine/*pharmacology Blood Glucose/metabolism Edrophonium/*pharmacology Female Gastric Inhibitory Polypeptide/blood Humans Insulin/*blood Male Obesity/*blood
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 15:58
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