New end take off: regulating cell polarity during the fission yeast cell cycle.

Details

Serval ID
serval:BIB_D9665FE627FC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
New end take off: regulating cell polarity during the fission yeast cell cycle.
Journal
Cell Cycle
Author(s)
Martin S.G., Chang F.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
4
Number
8
Pages
1046-1049
Language
english
Abstract
Cell polarization is a major event of the cell cycle and underlies the function of most cells. Cell polarity is often achieved through the coordinated organization of the microtubule and act in cytoskeletons. Dramatic changes in cell polarization occur during the cell cycle and are subject to regulation by cell cycle controls. Cells of the fission yeast Schizosaccharomyces pombe grow by tip extension in a cell cycle-controlled manner. During G2 phase, these cells exhibit a transition in cell polarization known as New End Take Off (NETO), in which monopolar cells initiate bipolar growth. Dynamic microtubules contribute to this process by depositing at cell ends the microtubule plus end proteins tea1p and tea4p, which are necessary for NETO. We discuss here how these proteins may recruit for 3p, a formin responsible for actin nucleation, as well as two other actin binding proteins, bud6p and sla2p, to initiate cell polarization at the new end of the cell. Thus, the study of NETO is revealing a mechanism by which the plus ends of microtubules regulate the spatial organization of actin.
Keywords
Actins/chemistry, Cell Cycle, Cytoskeleton/metabolism, G2 Phase, Microtubule-Associated Proteins/chemistry, Microtubule-Associated Proteins/physiology, Microtubules/chemistry, Microtubules/metabolism, Models, Biological, Mutation, Schizosaccharomyces/physiology, Schizosaccharomyces pombe Proteins/chemistry, Schizosaccharomyces pombe Proteins/physiology
Pubmed
Web of science
Create date
18/03/2008 11:32
Last modification date
20/08/2019 15:58
Usage data