Amoebal pathogens as emerging causal agents of pneumonia.

Details

Serval ID
serval:BIB_D945A0934C69
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Amoebal pathogens as emerging causal agents of pneumonia.
Journal
FEMS microbiology reviews
Author(s)
Lamoth F., Greub G.
ISSN
1574-6976 (Electronic)
ISSN-L
0168-6445
Publication state
Published
Issued date
05/2010
Peer-reviewed
Oui
Volume
34
Number
3
Pages
260-280
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Despite using modern microbiological diagnostic approaches, the aetiological agents of pneumonia remain unidentified in about 50% of cases. Some bacteria that grow poorly or not at all in axenic media used in routine clinical bacteriology laboratory but which can develop inside amoebae may be the agents of these lower respiratory tract infections (RTIs) of unexplained aetiology. Such amoebae-resisting bacteria, which coevolved with amoebae to resist their microbicidal machinery, may have developed virulence traits that help them survive within human macrophages, i.e. the first line of innate immune defence in the lung. We review here the current evidence for the emerging pathogenic role of various amoebae-resisting microorganisms as agents of RTIs in humans. Specifically, we discuss the emerging pathogenic roles of Legionella-like amoebal pathogens, novel Chlamydiae (Parachlamydia acanthamoebae, Simkania negevensis), waterborne mycobacteria and Bradyrhizobiaceae (Bosea and Afipia spp.).
Keywords
Afipia/pathogenicity, Amaranthaceae/microbiology, Amoebozoa/microbiology, Amoebozoa/pathogenicity, Bradyrhizobiaceae/pathogenicity, Chlamydiales/pathogenicity, Communicable Diseases, Emerging/microbiology, Communicable Diseases, Emerging/parasitology, Humans, Legionella/pathogenicity, Mycobacterium/pathogenicity, Pneumonia/microbiology, Pneumonia/parasitology
Pubmed
Web of science
Open Access
Yes
Create date
03/10/2019 16:16
Last modification date
04/10/2019 5:26
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