A primer on the molecular virology of hepatitis C

Details

Serval ID
serval:BIB_D8F24D141A6E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A primer on the molecular virology of hepatitis C
Journal
Liver International
Author(s)
Moradpour  D., Blum  H. E.
ISSN
1478-3223 (Print)
Publication state
Published
Issued date
12/2004
Volume
24
Number
6
Pages
519-25
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Dec
Abstract
Exciting advances have recently been made in the understanding of the molecular virology of hepatitis C. Powerful model systems have been developed that allow to systematically dissect important steps of the hepatitis C virus (HCV) life cycle. These include new systems for functional analyses of the HCV glycoproteins, providing insights into possible HCV receptors and cell entry mechanisms, and the replicon system, which has revolutionized investigation of HCV RNA replication and has facilitated drug discovery efforts. The largest gaps remain in the understanding of the virion structure and the processes that lead to the assembly, packaging and release of virions. However, given the pace of current HCV research, progress in these directions may be expected in the near future. Here, we provide a primer on the molecular virology of hepatitis C, with particular reference to novel antiviral targets and therapeutic strategies.
Keywords
Animals Antiviral Agents/therapeutic use DNA, Viral/*analysis Forecasting Hepacivirus/*genetics/physiology Hepatitis C/drug therapy/epidemiology/*genetics Hepatitis C, Chronic/drug therapy/epidemiology/genetics Humans Liver Cirrhosis/prevention & control Reverse Transcriptase Polymerase Chain Reaction/methods Risk Factors Viral Structural Proteins/analysis/*genetics Virus Replication/physiology
Pubmed
Web of science
Create date
25/01/2008 16:06
Last modification date
20/08/2019 15:58
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