Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.

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State: Public
Version: Final published version
Serval ID
serval:BIB_D8EED625AFFD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.
Journal
Molecular psychiatry
Author(s)
Kelly S., Jahanshad N., Zalesky A., Kochunov P., Agartz I., Alloza C., Andreassen O.A., Arango C., Banaj N., Bouix S., Bousman C.A., Brouwer R.M., Bruggemann J., Bustillo J., Cahn W., Calhoun V., Cannon D., Carr V., Catts S., Chen J., Chen J.X., Chen X., Chiapponi C., Cho K.K., Ciullo V., Corvin A.S., Crespo-Facorro B., Cropley V., De Rossi P., Diaz-Caneja C.M., Dickie E.W., Ehrlich S., Fan F.M., Faskowitz J., Fatouros-Bergman H., Flyckt L., Ford J.M., Fouche J.P., Fukunaga M., Gill M., Glahn D.C., Gollub R., Goudzwaard E.D., Guo H., Gur R.E., Gur R.C., Gurholt T.P., Hashimoto R., Hatton S.N., Henskens F.A., Hibar D.P., Hickie I.B., Hong L.E., Horacek J., Howells F.M., Hulshoff Pol H.E., Hyde C.L., Isaev D., Jablensky A., Jansen P.R., Janssen J., Jönsson E.G., Jung L.A., Kahn R.S., Kikinis Z., Liu K., Klauser P., Knöchel C., Kubicki M., Lagopoulos J., Langen C., Lawrie S., Lenroot R.K., Lim K.O., Lopez-Jaramillo C., Lyall A., Magnotta V., Mandl RCW, Mathalon D.H., McCarley R.W., McCarthy-Jones S., McDonald C., McEwen S., McIntosh A., Melicher T., Mesholam-Gately R.I., Michie P.T., Mowry B., Mueller B.A., Newell D.T., O'Donnell P., Oertel-Knöchel V., Oestreich L., Paciga S.A., Pantelis C., Pasternak O., Pearlson G., Pellicano G.R., Pereira A., Pineda Zapata J., Piras F., Potkin S.G., Preda A., Rasser P.E., Roalf D.R., Roiz R., Roos A., Rotenberg D., Satterthwaite T.D., Savadjiev P., Schall U., Scott R.J., Seal M.L., Seidman L.J., Shannon Weickert C., Whelan C.D., Shenton M.E., Kwon J.S., Spalletta G., Spaniel F., Sprooten E., Stäblein M., Stein D.J., Sundram S., Tan Y., Tan S., Tang S., Temmingh H.S., Westlye L.T., Tønnesen S., Tordesillas-Gutierrez D., Doan N.T., Vaidya J., van Haren NEM, Vargas C.D., Vecchio D., Velakoulis D., Voineskos A., Voyvodic J.Q., Wang Z., Wan P., Wei D., Weickert T.W., Whalley H., White T., Whitford T.J., Wojcik J.D., Xiang H., Xie Z., Yamamori H., Yang F., Yao N., Zhang G., Zhao J., van Erp TGM, Turner J., Thompson P.M., Donohoe G.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
23
Number
5
Pages
1261-1269
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
Keywords
Adult, Aged, Aged, 80 and over, Brain/physiopathology, Cohort Studies, Corpus Callosum/physiopathology, Diffusion Magnetic Resonance Imaging/methods, Diffusion Tensor Imaging/methods, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Schizophrenia/diagnostic imaging, Schizophrenia/physiopathology, White Matter/physiopathology, White Matter/ultrastructure, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2017 8:39
Last modification date
02/09/2019 5:26
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