An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.

Details

Serval ID
serval:BIB_D8EDE0F9AFDF
Type
Article: article from journal or magazin.
Collection
Publications
Title
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.
Journal
Thyroid
Author(s)
Peterson S.J., Cappola A.R., Castro M.R., Dayan C.M., Farwell A.P., Hennessey J.V., Kopp P.A., Ross D.S., Samuels M.H., Sawka A.M., Taylor P.N., Jonklaas J., Bianco A.C.
ISSN
1557-9077 (Electronic)
ISSN-L
1050-7256
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
28
Number
6
Pages
707-721
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at a symposium addressing hypothyroidism.
An online survey for hypothyroid patients was posted on the American Thyroid Association Web site and forwarded to multiple groups. Respondents were asked to rank satisfaction with their treatment for hypothyroidism and their treating physician. They also ranked their perception regarding physician knowledge about hypothyroidism treatments, need for new treatments, and life impact of hypothyroidism on a scale of 1-10. Respondents reported the therapy they were taking, categorized as LT4, LT4 and liothyronine (LT4 + LT3), or desiccated thyroid extract (DTE). They also reported sex, age, cause of hypothyroidism, duration of treatment, additional diagnoses, and prevalence of symptoms.
A total of 12,146 individuals completed the survey. The overall degree of satisfaction was 5 (interquartile range [IQR] = 3-8). Among respondents without self-reported depression, stressors, or medical conditions (n = 3670), individuals taking DTE reported a higher median treatment satisfaction of 7 (IQR = 5-9) compared to other treatments. At the same time, the LT4 treatment group exhibited the lowest satisfaction of 5 (IQR = 3-7), and for the LT4 + LT3 treatment group, satisfaction was 6 (IQR = 3-8). Respondents taking DTE were also less likely to report problems with weight management, fatigue/energy levels, mood, and memory compared to those taking LT4 or LT4 + LT3.
A subset of patients with hypothyroidism are not satisfied with their current therapy or their physicians. Higher satisfaction with both treatment and physicians is reported by those patients on DTE. While the study design does not provide a mechanistic explanation for this observation, future studies should investigate whether preference for DTE is related to triiodothyronine levels or other unidentified causes.
Keywords
Adult, Affect, Aged, Cognition, Depression, Emotions, Fatigue, Female, Health Knowledge, Attitudes, Practice, Hormone Replacement Therapy, Humans, Hypothyroidism/diagnosis, Hypothyroidism/drug therapy, Hypothyroidism/psychology, Internet, Male, Middle Aged, Patient Satisfaction, Physicians, Professional Competence, Quality of Life, Self Report, Surveys and Questionnaires, Thyroid Gland, Thyroxine/adverse effects, T3, TSH, combination therapy, desiccated thyroid extract, hypothyroidism, levothyroxine
Pubmed
Web of science
Create date
27/12/2020 13:01
Last modification date
28/12/2020 6:26
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