Lactate in the brain: from metabolic end-product to signalling molecule.

Details

Serval ID
serval:BIB_D8A400222E43
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lactate in the brain: from metabolic end-product to signalling molecule.
Journal
Nature reviews. Neuroscience
Author(s)
Magistretti P.J., Allaman I.
ISSN
1471-0048 (Electronic)
ISSN-L
1471-003X
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
19
Number
4
Pages
235-249
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.

Pubmed
Create date
15/03/2018 15:23
Last modification date
20/08/2019 15:58
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