Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex.

Details

Serval ID
serval:BIB_D89C8C49AD88
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Mangia S., Tkác I., Gruetter R., Van de Moortele P.F., Maraviglia B., Uğurbil K.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
2007
Volume
27
Number
5
Pages
1055-1063
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in the human visual cortex during two paradigms of visual stimulation lasting 5.3 and 10.6 mins. Significant concentration changes of approximately 0.2 micromol/g were observed for several metabolites: lactate increased by 23%+/-5% (P<0.0005), glutamate increased by 3%+/-1% (P<0.01), whereas aspartate decreased by 15%+/-6% (P<0.05). Glucose concentration also manifested a tendency to decrease during activation periods. The lactate concentration reached the new steady-state level within the first minute of activation and came back to baseline only after the stimulus ended. The changes of the concentration of metabolites implied a rise in oxidative metabolism to a new steady-state level during activation and indicated that amino-acid homeostasis is affected by physiological stimulation, likely because of an increased flux through the malate-aspartate shuttle.
Keywords
Adult, Amino Acids/metabolism, Aspartic Acid/metabolism, Female, Humans, Lactic Acid/metabolism, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Malates/metabolism, Male, Neurons/metabolism, Neurons/physiology, Oxidation-Reduction, Oxygen/blood, Visual Cortex/metabolism, Visual Cortex/physiology
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 15:58
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