Microbiota and Metabolite Modifications after Dietary Exclusion of Dairy Products and Reduced Consumption of Fermented Food in Young and Older Men.

Details

Serval ID
serval:BIB_D899D602E144
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Microbiota and Metabolite Modifications after Dietary Exclusion of Dairy Products and Reduced Consumption of Fermented Food in Young and Older Men.
Journal
Nutrients
Author(s)
Kim J., Burton-Pimentel K.J., Fleuti C., Blaser C., Scherz V., Badertscher R., Marmonier C., Lyon-Belgy N., Caille A., Pidou V., Blot A., Bertelli C., David J., Bütikofer U., Greub G., Dardevet D., Polakof S., Vergères G.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
01/06/2021
Peer-reviewed
Oui
Volume
13
Number
6
Pages
1905
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The gut microbiota adapts to age-related changes in host physiology but is also affected by environmental stimuli, like diet. As a source of both pre- and probiotics, dairy and fermented foods modulate the gut microbiota composition, which makes them interesting food groups to use for the investigation of interactions between diet and ageing. Here we present the effects of excluding dairy products and limiting fermented food consumption for 19 days on gut microbiota composition and circulating metabolites of 28 healthy, young (YA) and older (OA) adult men. The intervention affected gut microbial composition in both groups, with significant increases in Akkermansia muciniphila and decreases in bacteria of the Clostridiales order. Lower fasting levels of glucose and insulin, as well as dairy-associated metabolites like lactose and pentadecanoic acid, were observed after the intervention, with no effect of age. The intervention also decreased HDL and LDL cholesterol levels. Dairy fat intake was positively associated with the HDL cholesterol changes but not with the LDL/HDL ratio. In conclusion, restricting the intake of dairy and fermented foods in men modified their gut microbiota and blood metabolites, while the impact of the dietary restrictions on these outcomes was more marked than the effect of age.
Keywords
ageing, dairy products, fermented food, gut microbiota, lipids/free fatty acids
Pubmed
Web of science
Open Access
Yes
Create date
09/07/2021 10:48
Last modification date
10/09/2021 6:38
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