15 Jahre histopathologischer Synovialitis-Score : Rückblick und Weiterentwicklung eines diagnostischen Scores [Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score]
Details
Serval ID
serval:BIB_D879B403750D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
15 Jahre histopathologischer Synovialitis-Score : Rückblick und Weiterentwicklung eines diagnostischen Scores [Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score]
Journal
Zeitschrift fur Rheumatologie
ISSN
1435-1250 (Electronic)
ISSN-L
0340-1855
Publication state
Published
Issued date
08/2017
Peer-reviewed
Oui
Volume
76
Number
6
Pages
539-546
Language
german
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synovitis, meniscopathy-related synovitis and synovitis in hemochromatosis). Synovitis scores of between ≥ 5 and 9 are classified as high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme's arthritis, post-infection/reactive arthritis and peripheral arthritis in Bechterew disease); sensitivity is 61.7% and sensitivity 96.1%. According to receiver operating characteristic (ROC) analysis (AUC: 0.8-0.9), diagnostic value is good. National and international acceptance of the synovitis score has grown since the first publication in 2002 and a related follow-up publication in 2006. PubMed data analysis (as of 11.01.2017) yielded the following citation values according to "cited by PubMed Central articles" for two publications relating to the synovitis score: there were 29 cited-by-PubMed articles for DOI: 10.1078/0344-0338-5710261 , and 44 cited-in-PubMed articles for the second publication, DOI: 10.1111/j.1365-2559.2006.02508 . This makes a total of 73 PubMed citations over a period of 15 years, thereby evidencing the score's international acceptance. Immunohistochemical determination of a number of CD antigens relevant to inflammation has been proposed to further specify the synovitis score for the purposes of risk stratification of high-grade synovitis (e.g., risk of progression and sensitivity to biological agents).
Keywords
Arthritis, Psoriatic/diagnosis, Arthritis, Rheumatoid/diagnosis, Disease Progression, Humans, Osteoarthritis/diagnosis, Synovitis/diagnosis, Immunohistochemistry, Osteoarthritis, Rheumatoid arthritis, Synovial tissue, Synovitis
Pubmed
Web of science
Create date
11/01/2018 15:59
Last modification date
27/04/2024 7:05