Uric acid and hypertension: a focused review and practical recommendations.

Details

Serval ID
serval:BIB_D86C325760F0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Uric acid and hypertension: a focused review and practical recommendations.
Journal
Journal of hypertension
Author(s)
De Becker B., Borghi C., Burnier M., van de Borne P.
ISSN
1473-5598 (Electronic)
ISSN-L
0263-6352
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
37
Number
5
Pages
878-883
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
: Uric acid levels are higher in humans than in other mammals. Best known as an extracellular antioxidant, uric acid also increases salt sensitivity, fat storage, and lipogenesis. Xanthine oxidase-related oxidative stress may also induce endothelial dysfunction and renal vasoconstriction. Renal structure abnormalities contribute to salt-sensitive and uric acid-independent hypertension. Maternal hyperuricemia during pregnancy and hyperuricemia early in life are likewise independent risk factors for hypertension. Genetic polymorphism is potentially involved in the activity of xanthine oxidoreductase, but further studies are needed. Xanthine oxidase inhibition consistently decreases blood pressure in younger hypertensive patients, albeit modestly. Hyperuricemia affects one out of five adults as a result of the Western diet, insulin resistance, and renal dysfunction. This review advocates lifestyle changes to maintain uric acid levels within the normal range in young (pre)hypertensive individuals or normotensives with a family history of hypertension, metabolic disorders, or obesity; moreover, antihypertensive medications that increase uric acid levels should be avoided.
Keywords
Animals, Antioxidants/therapeutic use, Blood Pressure, Enzyme Inhibitors/therapeutic use, Humans, Hypertension/blood, Hypertension/complications, Hyperuricemia/complications, Kidney/abnormalities, Kidney Diseases, Oxidative Stress, Risk Factors, Uric Acid/blood, Urogenital Abnormalities/complications, Xanthine Oxidase/antagonists & inhibitors
Pubmed
Web of science
Create date
03/02/2019 15:10
Last modification date
07/07/2020 5:20
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