MRI signal and morphological alterations of the suprapatellar fat pad in asymptomatic subjects: are these normal variants?

Details

Serval ID
serval:BIB_D85E75B926AD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MRI signal and morphological alterations of the suprapatellar fat pad in asymptomatic subjects: are these normal variants?
Journal
Skeletal radiology
Author(s)
Cosentino A., Richard R., Baron M., Demondion X., Favre J., Omoumi P.
ISSN
1432-2161 (Electronic)
ISSN-L
0364-2348
Publication state
Published
Issued date
10/2022
Peer-reviewed
Oui
Volume
51
Number
10
Pages
1995-2007
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To study the prevalence of suprapatellar fat pad (SPFP) MR alterations in asymptomatic subjects, in relation to a wide range of clinical/imaging parameters, including muscle performance tests and physical activity data.
We prospectively included 110 asymptomatic subjects as part of a cohort study. Inclusion criteria were no knee pain in the last year. Exclusion criteria were any medical/surgical history of a knee disorder. Subjects underwent knee and low-dose posture radiographs [EOS®], 3 T MRI, clinical examination including muscle performance tests, and physical activity monitoring. The presence/absence of SPFP alterations (hyperintensity and mass effect) were assessed through consensus reading on fluid-sensitive sequences. Differences between groups of knees with SPFP alterations and controls were tested for a total of 55 categorical/continuous clinical/imaging parameters, including SPFP relative-T2-signal, trochlear/patellar/lower-limb morphologic measurements. Wilcoxon-rank-sum and chi-square tests were used to compare groups of patients. The histological correlation was obtained in a cadaveric specimen.
SPFP alterations were common in asymptomatic subjects: hyperintensity 57% (63/110) and mass effect 37% (41/110), with 27% (30/110) showing both. Among the 55 imaging, clinical, or activity parameters tested, only increased patellar tilt angle (p = 0.02) and TT-TG distance (p = 0.03) were statistically different between groups of SPFP alterations and controls. The histological correlation showed more abundant connective tissue in SPFP compared to the prefemoral fat pad.
SPFP hyperintensity and mass effect are common MRI findings in asymptomatic knees, and they are not related to most imaging, clinical, and activity parameters. Care should be taken not to overcall them pathological findings as they most likely represent normal variants.
Keywords
Adipose Tissue/diagnostic imaging, Adipose Tissue/pathology, Cohort Studies, Humans, Knee Joint/diagnostic imaging, Knee Joint/pathology, Magnetic Resonance Imaging/methods, Osteoarthritis, Knee/pathology, Impingement, Inflammation, Knee, MRI, Normal variants, Osteoarthritis, Radiography, Suprapatellar fat pad
Pubmed
Web of science
Open Access
Yes
Create date
25/04/2022 10:45
Last modification date
11/10/2022 5:39
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