Prevalence of Potential Drug-Drug Interactions in Patients of the Swiss HIV Cohort Study in the Era of HIV Integrase Inhibitors.

Details

Serval ID
serval:BIB_D84973BFC460
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of Potential Drug-Drug Interactions in Patients of the Swiss HIV Cohort Study in the Era of HIV Integrase Inhibitors.
Journal
Clinical infectious diseases
Author(s)
Deutschmann E., Bucher H.C., Jaeckel S., Gibbons S., McAllister K., Scherrer A.U., Braun D.L., Cavassini M., Hachfeld A., Calmy A., Battegay M., Cipriani M., Elzi L., Young J., Lopez-Centeno B., Berenguer J., Khoo S., Moffa G., Marzolini C.
Working group(s)
Swiss HIV Cohort Study
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Publication state
Published
Issued date
05/10/2021
Peer-reviewed
Oui
Volume
73
Number
7
Pages
e2145-e2152
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Prevalence of potential drug-drug interactions (PDDIs) between antiretroviral drugs (ARVs) and co-medications was high in 2008 in a Swiss HIV Cohort Study (SHCS) survey. We reassessed the prevalence of PDDIs in the era of human immunodeficiency virus (HIV) integrase inhibitors (INIs), characterized by more favorable interaction profiles.
The prevalence of PDDIs in treated HIV-positive individuals was assessed for the period 01-12/2018 by linkage of the Liverpool HIV drug interactions and SHCS databases. PDDIs were categorized as harmful (red flagged), of potential clinical relevance (amber flagged), or of weak clinical significance (yellow flagged).
In 9298 included individuals, median age was 51 years (IQR, 43-58), and 72% were males. Individuals received unboosted INIs (40%), boosted ARVs (30%), and nonnucleoside reverse transcriptase inhibitor (NNRTIs) (32%)-based regimens. In the entire cohort, 68% received ≥1 co-medication, 14% had polypharmacy (≥5 co-medications) and 29% had ≥1 PDDI. Among individuals with co-medication, the prevalence of combined amber and yellow PDDIs was 43% (33% amber-mostly with cardiovascular drugs-and 20% yellow-flagged PDDIs) compared to 59% in 2008. Two percent had red-flagged PDDIs (mostly with corticosteroids), the same as in the 2008 survey. Compared with 2008, fewer individuals received boosted ARVs (-24%) and NNRTIs (-13%) but the use of co-medications was higher.
Prevalence of PDDIs was lower with more widespread use of INIs in 2018 than in 2008. Continued use of boosted regimens and increasing needs for co-medications in this aging population impeded lower rates of PDDIs.
Keywords
Aged, Cohort Studies, Drug Interactions, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Integrase Inhibitors/adverse effects, Humans, Male, Middle Aged, Pharmaceutical Preparations, Prevalence, Switzerland/epidemiology, HIV, Swiss HIV Cohort Study, drug–drug interactions, modern antiretroviral therapy, prevalence
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2020 11:16
Last modification date
22/07/2022 5:38
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