Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae.

Details

Serval ID
serval:BIB_D8444BF49994
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae.
Journal
Microbes and Infection
Author(s)
Lamoth F., Pillonel T., Greub G.
ISSN
1769-714X (Electronic)
ISSN-L
1286-4579
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
17
Number
11-12
Pages
732-737
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Waddlia chondrophila is an emerging pathogen associated with abortion in cattle. In humans, a growing body of evidence supports its pathogenic role in miscarriage and in respiratory tract infection. The human pathogenicity of W. chondrophila is further supported by the presence of several virulence factors including a catalase, a functional T3SS and several adhesins. Despite this medical importance, no commercial tests are available and diagnostic of this strict intracellular bacterium mainly relies on serology, PCR and immunohistochemistry. So far, the epidemiology of W. chondrophila remains largely unexplored and zoonotic, waterborne or interhuman transmission has been considered. Apart from its pathogenic role, chlamydiologists are also interested in W. chondrophila in order to better understand biological mechanisms conserved and shared with Chlamydia spp. Indeed, W. chondrophila proved to be a useful model organism to study the pathobiology of chlamydiae thanks to its rapid replication, its large size allowing precise subcellular protein localization, as well as its growth in Dictyostelium amoebae.
Pubmed
Web of science
Create date
03/01/2016 17:36
Last modification date
20/08/2019 16:57
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