The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.

Details

Serval ID
serval:BIB_D80BD276A7D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.
Journal
Ocular immunology and inflammation
Author(s)
Agarwal A., Agrawal R., Gunasekaran D.V., Raje D., Gupta B., Aggarwal K., Murthy S.L., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Cunningham E., Nguyen Q.D., Pavesio C., Gupta V.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
27
Number
3
Pages
465-473
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.
Keywords
Adolescent, Adult, Aged, Antitubercular Agents/therapeutic use, Aqueous Humor/microbiology, Child, DNA, Bacterial/analysis, Eye Infections, Bacterial/diagnosis, Eye Infections, Bacterial/drug therapy, Eye Infections, Bacterial/microbiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/isolation & purification, Polymerase Chain Reaction/methods, Retrospective Studies, Tuberculosis, Ocular/diagnosis, Tuberculosis, Ocular/drug therapy, Tuberculosis, Ocular/microbiology, Uveitis/diagnosis, Uveitis/drug therapy, Uveitis/microbiology, Young Adult, Anti-tubercular therapy, choroidal tuberculoma, choroiditis, polymerase chain reaction, tuberculosis
Pubmed
Web of science
Create date
10/01/2018 8:17
Last modification date
05/08/2020 5:26
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