Influence of bacille Calmette-Guerin vaccination on size of tuberculin skin test reaction: to what size?

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Serval ID
serval:BIB_D8049C0FE270
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of bacille Calmette-Guerin vaccination on size of tuberculin skin test reaction: to what size?
Journal
Clinical Infectious Diseases
Author(s)
Tissot  F., Zanetti  G., Francioli  P., Zellweger  J.P., Zysset  F.
ISSN
1537-6591 (Electronic)
Publication state
Published
Issued date
01/2005
Volume
40
Number
2
Pages
211-7
Notes
Clinical Trial Journal Article --- Old month value: Jan 15
Abstract
BACKGROUND: Previous bacillus Calmette-Guerin (BCG) vaccination can confound the results of a tuberculin skin test (TST). We sought to determine a cutoff diameter of TST induration beyond which the influence of BCG vaccination was negligible in evaluating potential Mycobacterium tuberculosis infection in a population of health care workers with a high vaccination rate and low incidence of tuberculosis. METHODS: From 1991 through 1998, all new employees at the University Hospital of Lausanne, Switzerland, underwent a 2-step TST at entry visit. We also gathered information on demographic characteristics, along with factors commonly associated with tuberculin positivity, including previous BCG vaccination, history of latent M. tuberculosis infection, and predictors for M. tuberculosis infection. RESULTS: Among the 5117 investigated subjects, we found that influence of BCG vaccination on TST results varied across categories of age (likelihood ratio test, 0.0001). Prior BCG vaccination had a strong influence on skin test results of <or=18 mm in diameter among persons <40 years old, compared with the influence of factors predictive of M. tuberculosis infection. Prior latent M. tuberculosis infection and travel or employment in a country in which tuberculosis is endemic also had significant influences. CONCLUSIONS: Interpretation of TST reactions of <or=18 mm among BCG-vaccinated persons <40 years of age must be done with caution in areas with a low incidence of tuberculosis. In such a population, except for persons who have never been vaccinated, TST reactions of <or=18 mm are more likely to be the result of prior vaccination than infection and should not systematically lead to preventive treatment.
Keywords
Adolescent Adult Aging BCG Vaccine/*administration & dosage/*immunology Cohort Studies Emigration and Immigration Female Health Personnel Humans Male Middle Aged Odds Ratio Prospective Studies Skin/immunology/pathology Travel Tuberculin Test/*standards Tuberculosis/*diagnosis/immunology/prevention & control
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 18:08
Last modification date
25/09/2019 7:10
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