Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
Details
Serval ID
serval:BIB_D7FB7052C4A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
Journal
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
01/1996
Volume
173
Number
1
Pages
60-7
Language
english
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Abstract
Serum antibodies from human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were evaluated for virus neutralization and infection enhancement in vitro. Sera from LTNPs had higher average titers of neutralizing antibodies to HIV-1 strains IIIB and MN and more frequently neutralized primary isolates from progressors (14.9% vs. 1.3%, P = .002). Replication-competent HIV-1 was isolated from peripheral blood mononuclear cells and lymph nodes of 3 LTNPs. All viruses from LTNPs had a non-syncytium-inducing phenotype, were resistant to neutralization by autologous serum obtained at the time of virus isolation, and showed little evidence of a heightened sensitivity to neutralization by heterologous sera. Complement-mediated, antibody-dependent enhancement (C'-ADE) of HIV-1IIIB and primary isolates was equally prevalent for sera from LTNPs and non-LTNPs. Results indicate that LTNPs produce vigorous serum antibody responses and that long-term nonprogression is not associated with homologous neutralization or the absence of C'-ADE.
Keywords
Adult
CD4 Lymphocyte Count
Complement Membrane Attack Complex/immunology
Cytotoxicity, Immunologic/immunology
Disease Progression
Female
HIV Antibodies/*analysis
HIV Antigens/immunology
HIV Infections/*immunology
HIV Seropositivity/immunology
HIV-1/*immunology/isolation & purification
Humans
Immunophenotyping
Leukocytes, Mononuclear/virology
Lymph Nodes/virology
Male
Middle Aged
Neutralization Tests
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:14
Last modification date
20/08/2019 16:57