Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors

Details

Serval ID
serval:BIB_D7FB7052C4A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
Journal
Journal of Infectious Diseases
Author(s)
Montefiori D. C., Pantaleo G., Fink L. M., Zhou J. T., Zhou J. Y., Bilska M., Miralles G. D., Fauci A. S.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
01/1996
Volume
173
Number
1
Pages
60-7
Language
english
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Abstract
Serum antibodies from human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were evaluated for virus neutralization and infection enhancement in vitro. Sera from LTNPs had higher average titers of neutralizing antibodies to HIV-1 strains IIIB and MN and more frequently neutralized primary isolates from progressors (14.9% vs. 1.3%, P = .002). Replication-competent HIV-1 was isolated from peripheral blood mononuclear cells and lymph nodes of 3 LTNPs. All viruses from LTNPs had a non-syncytium-inducing phenotype, were resistant to neutralization by autologous serum obtained at the time of virus isolation, and showed little evidence of a heightened sensitivity to neutralization by heterologous sera. Complement-mediated, antibody-dependent enhancement (C'-ADE) of HIV-1IIIB and primary isolates was equally prevalent for sera from LTNPs and non-LTNPs. Results indicate that LTNPs produce vigorous serum antibody responses and that long-term nonprogression is not associated with homologous neutralization or the absence of C'-ADE.
Keywords
Adult CD4 Lymphocyte Count Complement Membrane Attack Complex/immunology Cytotoxicity, Immunologic/immunology Disease Progression Female HIV Antibodies/*analysis HIV Antigens/immunology HIV Infections/*immunology HIV Seropositivity/immunology HIV-1/*immunology/isolation & purification Humans Immunophenotyping Leukocytes, Mononuclear/virology Lymph Nodes/virology Male Middle Aged Neutralization Tests
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:14
Last modification date
20/08/2019 15:57
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