Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella.

Details

Serval ID
serval:BIB_D7EA1F90B7AF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella.
Journal
Journal of Endocrinological Investigation
Author(s)
Osella G., Orlandi F., Caraci P., Ventura M., Deandreis D., Papotti M., Bongiovanni M., Angeli A., Terzolo M.
ISSN
0391-4097 (Print)
ISSN-L
0391-4097
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
26
Number
2
Pages
163-169
Language
english
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Abstract
GH hyperproduction due to ectopic secretion of GHRH is a rare cause of acromegaly. Since 1959, approximately 50 cases of ectopic GHRH production from extrapituitary tumors have been described. Here we report the clinical and biochemical features of a 47-yr-old Caucasian woman with ectopic GHRH syndrome sustained by a bronchial carcinoid. The criteria for the diagnosis of acromegaly due to ectopic GHRH secretion were satisfied in our patient (i.e. confirmation of active GH hypersecretion, unequivocal demonstration of GHRH production and secretion from an extrapituitary tumor and cure of acromegaly after neoplasm removal). The tumor was an atypical carcinoid and there was a familial history of lung and colorectal cancer. Acromegaly was slightly active (mean GH value: 7.4 ng/ml, IGF-I: 436 ng/ml) and after tumor removal there was a progressive decline of GH levels, consistent with remission of pituitary somatotroph hyperplasia. Pituitary radiology showed an empty sella demonstrating for the first time its association with ectopic GHRH syndrome.
Keywords
Acromegaly/diagnosis, Acromegaly/etiology, Bronchial Neoplasms/complications, Bronchial Neoplasms/secretion, Carcinoid Tumor/secretion, Female, Growth Hormone-Releasing Hormone/secretion, Hormones, Ectopic/secretion, Human Growth Hormone/secretion, Humans, Middle Aged
Pubmed
Web of science
Create date
05/02/2015 14:39
Last modification date
20/08/2019 15:57
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