SGLT2 Inhibitors, What the Emergency Physician Needs to Know: A Narrative Review

Details

Serval ID
serval:BIB_D78919AA8999
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
SGLT2 Inhibitors, What the Emergency Physician Needs to Know: A Narrative Review
Journal
Journal of Clinical Medicine
Author(s)
Lu Henri, Lu Hortense, Kosinski Christophe, Wojtusciszyn Anne, Zanchi Anne, Carron Pierre-Nicolas, Müller Martin, Meyer Philippe, Martin Jehan, Muller Olivier, Hullin Roger
ISSN
2077-0383
Publication state
Published
Issued date
10/05/2021
Volume
10
Number
9
Pages
2036
Language
english
Abstract
Canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin belong to a class of antidiabetic treatments referred to as sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors, or SGLT2is). SGLT2is are currently indicated in North America and in Europe in type 2 diabetes mellitus, especially in patients with cardiovascular (CV) disease, high CV risk, heart failure, or renal disease. In Europe, dapagliflozin is also approved as an adjunct to insulin in patients with type 1 diabetes mellitus. New data provide evidence for benefits in heart failure with reduced ejection fraction and chronic kidney disease, including in patients without diabetes. The use of SGLT2is is expected to increase, suggesting that a growing number of patients will present to the emergency departments with these drugs. Most common adverse events are easily treatable, including mild genitourinary infections and conditions related to volume depletion. However, attention must be paid to some potentially serious adverse events, such as hypoglycemia (when combined with insulin or insulin secretagogues), lower limb ischemia, and diabetic ketoacidosis. We provide an up-to-date practical guide highlighting important elements on the adverse effects of SGLT2is and their handling in some frequently encountered clinical situations such as acute heart failure and decompensated diabetes.
Keywords
diabetes, heart failure, renal, guidelines
Web of science
Open Access
Yes
Create date
28/05/2021 17:59
Last modification date
08/06/2021 6:37
Usage data