Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure.
Details
State: Public
Version: author
Serval ID
serval:BIB_D738B0B2AF80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure.
Journal
American Journal of Physiology. Heart and Circulatory Physiology
ISSN
0363-6135
Publication state
Published
Issued date
11/2004
Peer-reviewed
Oui
Volume
287
Number
5
Pages
H2132-2137
Language
english
Notes
Publication types: Journal Article
Abstract
Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the elderly. Here, we studied cardiac performance in 4- to 5-mo-old (young) and 24- to 26-mo-old (old) Fischer 344 male rats using the Millar pressure-volume (P-V) conductance catheter system. We evaluated systolic and diastolic function in vivo at different preloads, including preload recruitable stroke work (PRSW), maximal slope of the systolic pressure increment (+dP/dt), and its relation to end-diastolic volume (+dP/dt-EDV) as well as the time constant of left ventricular pressure decay, as an index of relaxation. The slope of the end-diastolic P-V relation (EDPVR), an index of left ventricular stiffness, was also calculated. Aging was associated with decrease in left ventricular systolic pressure, +dP/dt, maximal slope of the diastolic pressure decrement, +dP/dt-EDV, PRSW, ejection fraction, stroke volume, cardiac and stroke work indexes, and efficiency. In contrast, total peripheral resistance, left ventricular end-diastolic volume, left ventricular end-diastolic pressure, and EDPVR were greater in aging than in young animals. Taken together, these data suggest that advanced aging is characterized by decreased systolic performance accompanied by delayed relaxation and increased diastolic stiffness of the heart in male Fischer 344 rats. P-V analysis is a sensitive method to determine cardiac function in rats.
Keywords
Aging, Animals, Blood Pressure, Cardiac Output, Low/etiology, Cardiac Output, Low/physiopathology, Diastole, Heart/physiopathology, Male, Rats, Rats, Inbred F344, Stroke Volume, Systole, Ventricular Function, Left, Ventricular Pressure, Ventricular Remodeling
Pubmed
Web of science
Create date
24/01/2008 18:00
Last modification date
20/08/2019 16:56