What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications

Details

Serval ID
serval:BIB_D71435D4A827
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications
Journal
Sleep
Author(s)
Boutrel Benjamin, Koob George F.
ISSN
0161-8105
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
27
Number
6
Pages
1181-1194
Language
english
Notes
SAPHIRID:67385
Abstract
Numerous studies dissecting the basic mechanisms that control sleep regulation have led to considerable improvement in our knowledge of sleep disorders. It is now well accepted that transitions between sleep and wakefulness are regulated by complex neurobiologic mechanisms, which, ultimately, can be delineated as oscillations between two opponent processes, one promoting sleep and the other promoting wakefulness. The role of several neurotransmitter or neuromodulator systems, including noradrenergic, serotonergic, cholinergic, adenosinergic, and histaminergic systems and, more recently, the hypocretin/orexin and dopamine systems, has been clearly established. Amphetamine-like stimulants are known to increase wakefulness by blocking dopamine reuptake, by stimulating dopamine release, or by both mechanisms. Modafinil may increase wakefulness through activation of noradrenergic and dopaminergic systems, possibly through interaction with the hypocretin/orexin system. Caffeine inhibits adenosinergic receptors, which in turn can produce activation via interaction with GABAergic and dopaminergic neurotransmission. Nicotine enhances acetylcholine neurotransmission in the basal forebrain and dopamine release. Understanding the exact role of the hypocretin/orexin and dopamine systems in the physiology and pharmacology of sleep-wake regulation may reveal new insights into current and future wakefulness-promoting drugs.
Pubmed
Web of science
Create date
11/03/2008 14:07
Last modification date
20/08/2019 15:56
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