Vitamin C supplementation in the critically ill patient.

Details

Serval ID
serval:BIB_D6E1857F4434
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Vitamin C supplementation in the critically ill patient.
Journal
Current Opinion in Clinical Nutrition and Metabolic Care
Author(s)
Berger M.M., Oudemans-van Straaten H.M.
ISSN
1473-6519 (Electronic)
ISSN-L
1363-1950
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
18
Number
2
Pages
193-201
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document type : review
Abstract
PURPOSE OF REVIEW: Vitamin C is not only an essential nutrient involved in many anabolic pathways, but also an important player of the endogenous antioxidant defense. Low plasma levels are very common in critical care patients and may reflect severe deficiency states.
RECENT FINDINGS: Vitamin C scavenges reactive oxygen species such as superoxide and peroxynitrite in plasma and cells (preventing damage to proteins, lipids and DNA), prevents occludin dephosphorylation and loosening of the tight junctions. Ascorbate improves microcirculatory flow impairment by inhibiting tumor-necrosis-factor-induced intracellular adhesion molecule expression, which triggers leukocyte stickiness and slugging. Clinical trials in sepsis, trauma and major burns testing high-dose vitamin C show clinical benefit. Restoration of normal plasma levels in inflammatory patients requires the administration of 3 g/day for several days, which is 30 times the daily recommended dose.
SUMMARY: The recent research on the modulation of oxidative stress and endothelial protection offer interesting therapeutic perspectives, based on the biochemical evidence, with limited or even absent side-effects.
Pubmed
Web of science
Create date
13/03/2015 18:32
Last modification date
20/08/2019 15:56
Usage data