Enhanced Mucosal Antibody Production and Protection against Respiratory Infections Following an Orally Administered Bacterial Extract
Details
Download: BIB_D6D10CBA06ED.P001.pdf (1027.97 [Ko])
State: Public
Version: Final published version
State: Public
Version: Final published version
Serval ID
serval:BIB_D6D10CBA06ED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enhanced Mucosal Antibody Production and Protection against Respiratory Infections Following an Orally Administered Bacterial Extract
Journal
Frontiers In Medicine
ISSN
2296-858X (Electronic)
ISSN-L
2296-858X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
1
Pages
41
Language
english
Notes
Publication types: Medicine ; research-article Identifiant PubMed Central: PMC4292070
Abstract
Secondary bacterial infections following influenza infection are a pressing problem facing respiratory medicine. Although antibiotic treatment has been highly successful over recent decades, fatalities due to secondary bacterial infections remain one of the leading causes of death associated with influenza. We have assessed whether administration of a bacterial extract alone is sufficient to potentiate immune responses and protect against primary infection with influenza, and secondary infections with either Streptococcus pneumoniae or Klebsiella pneumoniae in mice. We show that oral administration with the bacterial extract, OM-85, leads to a maturation of dendritic cells and B-cells characterized by increases in MHC II, CD86, and CD40, and a reduction in ICOSL. Improved immune responsiveness against influenza virus reduced the threshold of susceptibility to secondary bacterial infections, and thus protected the mice. The protection was associated with enhanced polyclonal B-cell activation and release of antibodies that were effective at neutralizing the virus. Taken together, these data show that oral administration of bacterial extracts provides sufficient mucosal immune stimulation to protect mice against a respiratory tract viral infection and associated sequelae.
Keywords
influenza, lung, super-infection
Pubmed
Open Access
Yes
Create date
11/07/2016 11:04
Last modification date
20/08/2019 16:56