Can 3T multiparametric magnetic resonance imaging accurately detect prostate cancer extracapsular extension?

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State: Public
Version: author
Serval ID
serval:BIB_D6CAE6A7B117
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Can 3T multiparametric magnetic resonance imaging accurately detect prostate cancer extracapsular extension?
Journal
Canadian Urological Association Journal = Journal De L'association Des Urologues Du Canada
Author(s)
Cerantola Y., Valerio M., Kawkabani Marchini A., Meuwly J.Y., Jichlinski P.
ISSN
1911-6470 (Print)
ISSN-L
1911-6470
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
7
Number
11-12
Pages
E699-E703
Language
english
Abstract
BACKGROUND: Accurate staging is essential to determine the correct management of patients diagnosed with prostate cancer. We assess the accuracy of 3T multiparametric magnetic resonance imaging (MRI) with endorectal coil (3TemMRI) in detecting prostate cancer local extension.
METHODS: We retrospectively reviewed charts from January 2008 to July 2012 from all patients undergoing radical prostatectomy. Patients were only included if 3TemMRI and radical prostatectomy were performed at our institution. Based on the presence of extracapsular extension (ECE) at 3TemMRI, prostate cancer was dichotomized into locally advanced or organ-confined disease. The accuracy of 3TemMRI local staging was then evaluated using definitive pathology as a reference.
RESULTS: Overall, 177 radical prostatectomies were performed within the timeframe. After applying exclusion criteria, 60 patients were included in the final analysis. The mean patient age was 67 ± 7 (standard deviation) years. Mean prostate-specific antigen value was 12.7 ± 12.7 ng/L. Based on preoperative characteristics, we considered 38 of the 60 patients (63%) patients high risk. 3TemMRI identified an organ-confined tumour in 46 patients and locally advanced disease in 14 patients. When correlated to final pathology, 3TemMRI specificity, sensitivity, negative and positive predictive values, and accuracy in detecting locally advanced prostate cancer were 90%, 35%, 57%, 79% and 62%, respectively.
INTERPRETATION: This study shows that the use of preoperative 3TemMRI can be used to identify organ-confined prostate cancer when locally advanced disease is suspected.
Pubmed
Web of science
Open Access
Yes
Create date
27/01/2014 12:05
Last modification date
20/08/2019 16:56
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