Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.

Details

Serval ID
serval:BIB_D6B2134FFAED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.
Journal
Journal of immunology
Author(s)
Chennupati V., Koch U., Coutaz M., Scarpellino L., Tacchini-Cottier F., Luther S.A., Radtke F., Zehn D., MacDonald H.R.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Publication state
Published
Issued date
01/08/2016
Peer-reviewed
Oui
Volume
197
Number
3
Pages
771-782
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis of several well-characterized populations of innate-like T cells including invariant NKT cells (iNKT), CD8ααTCRαβ small intestinal intraepithelial lymphocytes, and innate memory phenotype CD8 T cells is controlled by Notch. Notch selectively regulates hepatic iNKT cell survival via tissue-restricted control of B cell lymphoma 2 and IL-7Rα expression. More generally, Notch regulation of innate-like T cell homeostasis involves both cell-intrinsic and -extrinsic mechanisms and relies upon context-dependent interactions with Notch ligand-expressing fibroblastic stromal cells. Collectively, using conditional ablation of Notch receptors on peripheral T cells or Notch ligands on putative fibroblastic stromal cells, we show that Notch signaling is indispensable for the homeostasis of three tissue-restricted populations of innate-like T cells: hepatic iNKT, CD8ααTCRαβ small intestinal intraepithelial lymphocytes, and innate memory phenotype CD8 T cells, thus supporting a generalized role for Notch in innate T cell homeostasis.

Keywords
Animals, Cell Differentiation/immunology, Flow Cytometry, Homeostasis/immunology, Immunohistochemistry, Mice, Mice, Transgenic, Receptors, Notch/immunology, Receptors, Notch/metabolism, Signal Transduction/immunology, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
24/06/2016 8:17
Last modification date
20/08/2019 15:56
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