Impact of High Altitude on Cardiovascular Health: Current Perspectives.

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State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_D67D4EBE5867
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Impact of High Altitude on Cardiovascular Health: Current Perspectives.
Journal
Vascular health and risk management
Author(s)
Mallet R.T., Burtscher J., Richalet J.P., Millet G.P., Burtscher M.
ISSN
1178-2048 (Electronic)
ISSN-L
1176-6344
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
17
Pages
317-335
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more than 100 million lowlanders visit mountainous areas above 2500 m annually. The interactions between the low barometric pressure and partial pressure of O <sub>2</sub> , climate, individual genetic, lifestyle and socio-economic factors, as well as adaptation and acclimatization processes at high elevations are extremely complex. It is challenging to decipher the effects of these myriad factors on the cardiovascular health in high altitude residents, and even more so in those ascending to high altitudes with or without preexisting diseases. This review aims to interpret epidemiological observations in high-altitude populations; present and discuss cardiovascular responses to acute and subacute high-altitude exposure in general and more specifically in people with preexisting cardiovascular diseases; the relations between cardiovascular pathologies and neurodegenerative diseases at altitude; the effects of high-altitude exercise; and the putative cardioprotective mechanisms of hypobaric hypoxia.
Keywords
acclimatization, adaptation, conditioning, exercise, hypobaria, hypoxia
Pubmed
Open Access
Yes
Create date
29/06/2021 10:36
Last modification date
23/11/2022 7:15
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