Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population.

Details

Serval ID
serval:BIB_D67A741E91C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population.
Journal
iScience
Author(s)
Clark C., Gholam M., Zullo L., Kerksiek A., Castelao E., von Gunten A., Preisig M., Lütjohann D., Popp J.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
16/06/2023
Peer-reviewed
Oui
Volume
26
Number
6
Pages
106740
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with neurodegeneration and cognitive decline. Here we performed multivariate analysis in 720 individuals enrolled in a population-based prospective study to determine whether circulating cholesterol precursors and metabolites, triglycerides, and phytosterols, are associated with cognitive impairment and decline in the older population. We report specific dysregulations of endogenous cholesterol synthesis and metabolism, and diet-derived phytosterols, and their changes over time associated with cognitive impairment, and decline in the general population. These findings suggest circulating sterols levels could be considered in risk evaluation and are relevant for the development of strategies to prevent cognitive decline in older people.
Keywords
Age, Behavioral neuroscience, Human metabolism
Pubmed
Web of science
Open Access
Yes
Create date
05/06/2023 8:39
Last modification date
14/12/2023 7:12
Usage data