Pregnancy following combined growth hormone--pulsatile GnRH treatment in a patient with hypothalamic amenorrhoea.

Details

Serval ID
serval:BIB_D66E4480C626
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Pregnancy following combined growth hormone--pulsatile GnRH treatment in a patient with hypothalamic amenorrhoea.
Journal
Human Reproduction
Author(s)
Volpe A., Coukos G., Artini P.G., Silferi M., Petraglia F., Boghen M., D'Ambrogio G.D., Genazzani A.R.
ISSN
0268-1161 (Print)
ISSN-L
0268-1161
Publication state
Published
Issued date
1990
Volume
5
Number
3
Pages
345-347
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
A patient with hypothalamic amenorrhoea and a poor response in terms of pituitary growth hormone (GH) to acute administration of growth hormone-releasing factor has been treated with pulsatile gonadotrophin-releasing hormone (GnRH) combined with GH to induce ovulation. GH was administered daily until signs of ovulation were detected. The luteal phase was supported by pulsatile GnRH only. Combined treatment gave an improved follicular recruitment, higher plasma levels of 17 beta-oestradiol and an earlier ovulation, compared to the previous cycle with pulsatile GnRH only. The result was a twin pregnancy which ended with the birth of two healthy male babies. The role of GH in potentiating the ovarian response to gonadotrophins, as well as the GH secretion abnormalities associated with dysfunctions of the hypothalamic - pituitary - gonadal axis, might provide a rationale for combined GH and pulsatile GnRH treatment in such patients.
Keywords
Adult, Amenorrhea/drug therapy, Drug Therapy, Combination, Estradiol/biosynthesis, Female, Growth Hormone/therapeutic use, Growth Hormone-Releasing Hormone/therapeutic use, Humans, Hypothalamus/physiopathology, Ovulation Induction, Pregnancy, Pregnancy, Multiple/drug effects, Pulsatile Flow
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 15:56
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