Effects of a short-term overfeeding with fructose or glucose in healthy young males.

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Serval ID
serval:BIB_D665D2D205FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of a short-term overfeeding with fructose or glucose in healthy young males.
Journal
British Journal of Nutrition
Author(s)
Ngo Sock E.T.,  K.A., Ith M., Kreis R., Boesch C., Tappy L.
ISSN
1475-2662 (Electronic)
ISSN-L
0007-1145
Publication state
Published
Issued date
07/2010
Volume
103
Number
7
Pages
939-943
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Abstract
Consumption of simple carbohydrates has markedly increased over the past decades, and may be involved in the increased prevalence in metabolic diseases. Whether an increased intake of fructose is specifically related to a dysregulation of glucose and lipid metabolism remains controversial. We therefore compared the effects of hypercaloric diets enriched with fructose (HFrD) or glucose (HGlcD) in healthy men. Eleven subjects were studied in a randomised order after 7 d of the following diets: (1) weight maintenance, control diet; (2) HFrD (3.5 g fructose/kg fat-free mass (ffm) per d, +35 % energy intake); (3) HGlcD (3.5 g glucose/kg ffm per d, +35 % energy intake). Fasting hepatic glucose output (HGO) was measured with 6,6-2H2-glucose. Intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL) were measured by 1H magnetic resonance spectroscopy. Both fructose and glucose increased fasting VLDL-TAG (HFrD: +59 %, P < 0.05; HGlcD: +31 %, P = 0.11) and IHCL (HFrD: +52 %, P < 0.05; HGlcD: +58 %, P = 0.06). HGO increased after both diets (HFrD: +5 %, P < 0.05; HGlcD: +5 %, P = 0.05). No change was observed in fasting glycaemia, insulin and alanine aminotransferase concentrations. IMCL increased significantly only after the HGlcD (HFrD: +24 %, NS; HGlcD: +59 %, P < 0.05). IHCL and VLDL-TAG were not different between hypercaloric HFrD and HGlcD, but were increased compared to values observed with a weight maintenance diet. However, glucose led to a higher increase in IMCL than fructose.
Keywords
Alanine Transaminase/blood, Blood Glucose/metabolism, Cholesterol, VLDL/blood, Diet, Dietary Sucrose/administration & dosage, Energy Intake, Fasting, Fructose/administration & dosage, Glucose/administration & dosage, Humans, Insulin/blood, Lipid Metabolism, Liver/drug effects, Liver/metabolism, Male, Muscle Cells/drug effects, Muscle Cells/metabolism, Overnutrition/metabolism, Triglycerides/blood, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2011 14:47
Last modification date
25/09/2019 6:10
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