Stimulus-response curve of human motor nerves: multicenter assessment of various indexes.

Details

Serval ID
serval:BIB_D64616C7FEAB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stimulus-response curve of human motor nerves: multicenter assessment of various indexes.
Journal
Neurophysiologie Clinique = Clinical Neurophysiology
Author(s)
Boërio D., Hogrel J.Y., Lefaucheur J.P., Wang F.C., Verschueren A., Pouget J., Carrera E., Kuntzer T.
ISSN
0987-7053
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
38
Number
1
Pages
31-38
Language
english
Abstract
The value of various indexes to characterize the stimulus-response curve of human motor nerves was assessed in 40 healthy subjects recruited from four European centers of investigation (Créteil, Lausanne, Liège, Marseille). Stimulus-response curves were established by stimulating the right median and ulnar motor nerves at the wrist, with stimulus durations of 0.05 and 0.5 ms. The following parameters were studied: the threshold intensity of stimulation to obtain 10% (I 10), 50% (I 50), and 90% (I 90) of the maximal compound muscle action potential, the ratios I 10/I 50, I 90/I 50, (I 90 - I 10)/I 10, (I 90-I 50)/I 50, and (I 50 - I 10)/I 10, and the slopes of the stimulus-response curves with or without normalization to I 50. For each parameter, within-center variability and reproducibility (in a test-retest study) were assessed and between-center comparisons were made. For most of the parameters, the results varied significantly within and between the centers. Within the centers, only the ratios I 10/I 50 and I 90/I 50 were found constant and reproducible. Between the centers, the absolute intensity thresholds (I 10, I 50, I 90) and the ratio I 90/I 50 did not show significant differences at stimulus duration of 0.5 ms, whatever the stimulated nerve. The reduced variability and good reproducibility of the ratios I 10/I 50 and I 90/I 50 open perspectives in neurophysiological practice for the use of these indexes of the stimulus-response curve, a rapid and noninvasive test.
Keywords
Action Potentials/physiology, Adult, Algorithms, Electric Stimulation, Electrodiagnosis, Electromyography, Europe, Female, Humans, Male, Median Nerve/physiology, Middle Aged, Motor Neurons/physiology, Peripheral Nerves/physiology, Reproducibility of Results, Skin Temperature/physiology, Ulnar Nerve/physiology
Pubmed
Web of science
Create date
30/09/2009 13:31
Last modification date
20/08/2019 15:56
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