Interaction between the hypothalamo-pituitary-adrenal axis and the immunological system

Details

Serval ID
serval:BIB_D641F227CC4A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Interaction between the hypothalamo-pituitary-adrenal axis and the immunological system
Journal
Annales d'Endocrinologie
Author(s)
Gaillard R. C.
ISSN
0003-4266
Publication state
Published
Issued date
04/2001
Peer-reviewed
Oui
Volume
62
Number
2
Pages
155-163
Notes
Journal Article Review --- Old month value: Apr
Abstract
The endocrine and immune systems are interrelated via a bidirectional network in which hormones affect immune function and, in turn, immune responses are reflected in neuroendocrine changes. This bidirectional communication is possible because both systems share a common "chemical language" that results from a sharing of common ligands (hormones and cytokines) and their specific receptors. Cytokines are important partners in this crosstalk. They play a role in modulating the hypothalamo-pituitary-adrenal (HPA) axis responses at all three levels: the hypothalamus, the pituitary gland and the adrenals. Acute effects of cytokines are produced at the central nervous system level, particularly the hypothalamus, whereas pituitary and adrenal actions are slower and are probably involved during prolonged exposure to cytokines such as during chronic inflammation or infection. Several mechanisms have been proposed by which peripheral cytokines may gain access to the brain. They include an active transport through the blood-brain barrier, a passage at the circumventricular organ level, as well as a neuronal pathway through the vagal nerve. The immune-neuroendocrine interactions are involved in numerous physiological and pathophysiological conditions and the interactions with the HPA axis may represent a mechanism through which the immune system, by stimulating the production of glucocorticoids, avoids an overshoot of inflammatory response. The crosstalk between the immune and endocrine systems is important to homeostasis, since the interactions can produce various appropriate adaptative responses when homeostasis is threatened.
Keywords
Adrenal Glands/*physiology Animals Brain/metabolism Cytokines/biosynthesis/metabolism/pharmacology Humans Hypothalamus/*physiology *Immunity Pituitary Gland/*physiology
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 15:56
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