Cyclosporine causes sympathetically mediated elevations in arterial pressure in rats

Details

Serval ID
serval:BIB_D62522C5B3B8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cyclosporine causes sympathetically mediated elevations in arterial pressure in rats
Journal
Hypertension
Author(s)
Morgan  B. J., Lyson  T., Scherrer  U., Victor  R. G.
ISSN
0194-911X (Print)
Publication state
Published
Issued date
10/1991
Volume
18
Number
4
Pages
458-66
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Abstract
Cyclosporine-induced immunosuppression has emerged as a new cause of hypertension, but the underlying mechanisms are poorly understood. In patients, this hypertension is accompanied by sympathetic neural activation. We therefore hypothesized that increased sympathetic nerve discharge is an important mechanism by which cyclosporine raises blood pressure. To test this hypothesis, we examined effects of acute administration of cyclosporine (5 mg/kg i.v.) or vehicle on renal and lumbar sympathetic nerve activity, renal and femoral blood flow velocity (pulsed Doppler flowmetry), and arterial pressure in chloralose-anesthetized rats. Vehicle had no effect on sympathetic nerve activity, whereas cyclosporine caused renal and lumbar sympathetic nerve activity to increase progressively over 60 minutes to levels that were 362 +/- 46% and 388 +/- 70%, respectively, of the baseline values (p less than 0.05). These increases in sympathetic nerve activity were accompanied by proportional increases in renal and femoral vascular resistance and sustained increases in mean arterial pressure (+19 +/- 3 mm Hg, p less than 0.05 versus baseline). The cyclosporine-induced increases in regional vascular resistance and arterial pressure were greatly attenuated, or abolished, by ganglionic blockade or by clonidine (central sympatholysis) but were unaffected by angiotensin converting enzyme inhibition. These findings demonstrate that in an anesthetized animal preparation, the vasoconstrictor and blood pressure-raising effects of cyclosporine are caused by sympathetic neural activation.
Keywords
Animals Blood Pressure/*drug effects Cyclosporine/*pharmacology Female Rats Rats, Inbred Strains Sympathetic Nervous System/*drug effects/physiology Vasoconstriction/drug effects
Pubmed
Web of science
Create date
25/01/2008 14:04
Last modification date
20/08/2019 15:55
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