Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection
Details
Serval ID
serval:BIB_D62142E866A1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection
Journal
Tissue Antigens
ISSN
0001-2815 (Print)
Publication state
Published
Issued date
04/2007
Volume
69 Suppl 1
Pages
237-40
Notes
Journal Article --- Old month value: Apr
Abstract
An estimated 2%-3% of the world's population is chronically infected with hepatitis C virus (HCV) and this is a major cause of liver disease worldwide. Following acute infection, outcome is variable with acute HCV successfully resolved in some individuals (20%-30%), but in the majority of cases the virus is able to persist. Co-infection with human immunodeficiency virus has been associated with a negative impact on the course of HCV infection. The host's immune response is an important correlate of HCV infection outcome and disease progression. Natural killer (NK) cells provide a major component of the antiviral immune response by recognising and killing virally infected cells. NK cells modulate their activity through a combination of inhibitory and activatory receptors such as the killer immunoglobulin-like receptors (KIRs) that bind to human leukocyte antigen (HLA) Class I molecules. In this workshop component, we addressed the influence of KIR genotypes and their HLA ligands on resolving HCV infection and we discuss the implications of the results of the study of Lopez-Vazquez et al. on KIR and HCV disease progression.
Keywords
Alleles
Female
HLA-C Antigens/*genetics/immunology/metabolism
Hepacivirus/physiology
Hepatitis C/genetics/*immunology/virology
Humans
Killer Cells, Natural/*immunology
Ligands
Male
RNA, Viral/genetics
Receptors, Immunologic/*genetics/metabolism
Pubmed
Web of science
Create date
25/01/2008 14:45
Last modification date
20/08/2019 15:55