Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort.

Details

Serval ID
serval:BIB_D60CCA654910
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort.
Journal
Neurobiology of aging
Author(s)
Trofimova O., Loued-Khenissi L., DiDomenicantonio G., Lutti A., Kliegel M., Stringhini S., Marques-Vidal P., Vollenweider P., Waeber G., Preisig M., Kherif F., Draganski B.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
102
Pages
50-63
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Given the controversy about the impact of modifiable risk factors on mood and cognition in ageing, we sought to investigate the associations between cardio-vascular risk, mental health, cognitive performance and brain anatomy in mid- to old age. We analyzed a set of risk factors together with multi-parameter magnetic resonance imaging (MRI) in the CoLaus|PsyCoLaus cohort (n > 1200). Cardio-vascular risk was associated with differences in brain tissue properties - myelin, free tissue water, iron content - and regional brain volumes that we interpret in the context of micro-vascular hypoxic lesions and neurodegeneration. The interaction between clinical subtypes of major depressive disorder and cardio-vascular risk factors showed differential associations with brain structure depending on individuals' lifetime trajectory. There was a negative correlation between melancholic depression, anxiety and MRI markers of myelin and iron content in the hippocampus and anterior cingulate. Verbal memory and verbal fluency performance were positively correlated with left amygdala volumes. The concomitant analysis of brain morphometry and tissue properties allowed for a neuro-biological interpretation of the link between modifiable risk factors and brain health.
Keywords
adult, aging, amygdala, anterior cingulate, anxiety, article, brain size, brain tissue, cardiovascular risk factor, controlled study, hippocampus, human, major depression, melancholia, mental health, mood, morphometry, nerve degeneration, nuclear magnetic resonance imaging, risk assessment, tissue water, verbal memory, iron, myelin, Aging, Cardiovascular disease, Cognition, Major depressive disorder, Quantitative magnetic resonance imaging
Pubmed
Web of science
Open Access
Yes
Create date
17/03/2021 13:04
Last modification date
03/07/2021 6:32
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