Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia.
Details
Serval ID
serval:BIB_D5FCC4BD1B33
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia.
Journal
Journal of Cerebral Blood Flow and Metabolism
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1987
Volume
7
Number
4
Pages
394-402
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with 1H and 31P nuclear magnetic resonance spectroscopy. We demonstrate a threshold flow value for the metabolic changes associated with energy failure at a level similar to the values previously reported for electrical failure and tissue water accumulation, but higher than that associated with breakdown of extracellular potassium homeostasis.
Keywords
Animals, Aspartic Acid/analogs & derivatives, Aspartic Acid/metabolism, Brain/metabolism, Brain Ischemia/metabolism, Brain Ischemia/physiopathology, Cerebrovascular Circulation, Energy Metabolism, Gerbillinae, Hydrogen/diagnostic use, Hydrogen-Ion Concentration, Lactates/metabolism, Lactic Acid, Magnetic Resonance Spectroscopy/diagnostic use, Phosphocreatine/metabolism, Phosphorus/diagnostic use
Pubmed
Web of science
Create date
08/10/2011 15:35
Last modification date
20/08/2019 16:55
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