Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study.

Details

Serval ID
serval:BIB_D5DD8D66EA43
Type
Article: article from journal or magazin.
Collection
Publications
Title
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study.
Journal
Journal of human genetics
Author(s)
Mollaki V., Georgiadis T., Tassidou A., Ioannou M., Daniil Z., Koutsokera A., Papathanassiou A.A., Zintzaras E., Vassilopoulos G.
ISSN
1435-232X (Electronic)
ISSN-L
1434-5161
Publication state
Published
Issued date
11/2009
Peer-reviewed
Oui
Volume
54
Number
11
Pages
655-659
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Toll-like receptors (TLRs) and myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms may be involved in the pathogenesis of Hodgkin's lymphoma (HL) through altered immunoregulatory and inflammatory responses. A candidate-gene association study was conducted to investigate the association between TLR9 -1237T>C, TLR9 2848A>G, MYD88 -938C>A and MYD88 1944C>G gene polymorphisms and the risk for HL. The impact of haplotypes was also examined. The study showed that carriership for -1237C and 2848A was associated with an increased risk for HL (odds ratio (OR)=2.53 (1.36-4.71) and OR=6.20 (1.3-28.8)). The MYD88 polymorphisms produced nonsignificant results. The estimated frequencies of the TLR9/1237C-2848A and MYD88/938C-1944G haplotypes were also significantly different between HL and controls (P<0.01). In addition, a significant difference between HL and controls was observed for the TLR9/1237C-TLR9/2848A-MYD88/938C-MYD88/1944C haplotypes (P<0.01). In conclusion, our study showed that TLR polymorphisms, and TLR9 and MYD88 haplotypes are related to the development of HL.
Keywords
Adult, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Haplotypes, Hodgkin Disease/genetics, Humans, Linkage Disequilibrium, Male, Middle Aged, Myeloid Differentiation Factor 88/genetics, Odds Ratio, Polymorphism, Single Nucleotide, Toll-Like Receptor 9/genetics, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2019 18:41
Last modification date
21/08/2019 5:32
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