Ischemic heart disease

Details

Serval ID
serval:BIB_D5D0A8577C89
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Ischemic heart disease
Title of the book
Cardiac pathology
Author(s)
Michaud K.
Publisher
Springer-Verlag London
Address of publication
Sheffield Teaching Hospitals, Sheffield, U.K.
ISBN
978-1-4471-2406-1
Publication state
Published
Issued date
2013
Editor
Survana S.K.
Chapter
7
Pages
117-131
Edition
1rst ed.
Language
english
Abstract
Ischaemic heart disease as the result of impaired blood supply is currently the leading cause of failure and death. Ischaemic heart disease refers to a group of clinicopathological symptoms including angina pectoris, acute myocardial infection, chronic ischemic heart disease, as well as heart failure and sudden cardiac death. Coronary artery ischemic heart disease, as well as heart failure and sudden cardiac death. Coronary artery thrombosis is the most common cause of acute myocardial infarction and sudden cardiac death. A thrombotic event is the result of two different processes: plaque disruption and endothelial erosion. The morphology of a "vulnerable plaque" is more clinically indicative than the plaque volume and the degree of luminal stenosis. However, identification of patients with vulnerable plaques remains very challenging and demands the development of new methods of coronary plaque imaging. Sudden death resulting from ventricular fibrillation or AV block frequently complicates coronary thrombosis, accounting for up to 50% of mortality.If a coronary artery is occluded for more than 20 min, irreversible damage to the pericardium occurs. Timely coronary recanalization and myocardial reperfusion limit the extent of myocardial necrosis, but may induce "reperfusion injuries", stunned myocardium, or reperfused myocardial hemorrhagic infarcts, all of which are related to infarct siz and coronary occlusion time. Reperfusion injuries have been described after cardiac surgery, percutaneous transluminal coronary angioplasty, and fibrinolysis. A prolonged imbalance between the supply of and demand for myocardial oxygen and nutrition leads to a subacute, acute, or chronic state (aka hibernating myocardium) of myocardial ischemia. Ischemic heart disease is bwelieved to be the underlying cause of heart failure in approximately two-thirds of patients, resulting from acute and/or chronic injury to the heart.
Keywords
Ischaemic heart disease, Coronary thrombosis, Sudden cardiac death, Coronary plaque, Myocardial infarct, Plaque disruption, Stunned myocardium
Create date
22/02/2013 14:46
Last modification date
20/08/2019 15:55
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