Inhaled NO preadministration modulates local and remote ischemia-reperfusion organ injury in a rat model

Details

Serval ID
serval:BIB_D5B52D0095E4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Inhaled NO preadministration modulates local and remote ischemia-reperfusion organ injury in a rat model
Journal
J Appl Physiol (1985)
Author(s)
Guery B., Neviere R., Viget N., Foucher C., Fialdes P., Wattel F., Beaucaire G.
ISSN
8750-7587 (Print)
ISSN-L
0161-7567
Publication state
Published
Issued date
07/1999
Volume
87
Number
1
Pages
47-53
Language
english
Notes
Guery, B
Neviere, R
Viget, N
Foucher, C
Fialdes, P
Wattel, F
Beaucaire, G
eng
Research Support, Non-U.S. Gov't
J Appl Physiol (1985). 1999 Jul;87(1):47-53. doi: 10.1152/jappl.1999.87.1.47.
Abstract
Inhaled nitric oxide (iNO) has been shown to have a protective effect in lung ischemia-reperfusion (I/R)-induced injuries. We studied the role of iNO (10 parts/million for 4 h) administered before I/R. In an isolated perfused lung preparation, iNO decreased the extravascular albumin accumulation from 2,059 +/- 522 to 615 +/- 105 microl and prevented the increase in lung wet-to-dry weight ratio. To study the mechanisms of this prevention, we evaluated the role of nitric oxide (NO) transport and lung exposure with matched experiments by using either lungs or blood of animals exposed to iNO and blood or lungs of naive animals. iNO-exposed blood with naive lungs did not limit the extravascular albumin accumulation (2,561 +/- 397 microl), but iNO-exposed lungs showed a leak not significantly different from the group in which both lungs and blood were iNO exposed (855 +/- 224 vs. 615 +/- 105 microl). An improvement in heart I/R left ventricular developed pressure in the animals exposed to iNO showed that blood-transported NO was, however, sufficient to trigger remote organ endothelium and reduce the consequences of a delayed injury. In conclusion, preventive iNO reduces the consequences of lung I/R injuries by a mechanism based on tissue or endothelium triggering.
Keywords
Administration, Inhalation, Albumins/metabolism, Animals, Disease Models, Animal, In Vitro Techniques, Lung/blood supply/*drug effects, *Lung Injury, Myocardial Reperfusion Injury/prevention & control, Nitric Oxide/*administration & dosage/blood, Organ Size/drug effects, Pulmonary Circulation/drug effects, Rats, Rats, Sprague-Dawley, Reperfusion Injury/*prevention & control
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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