Classification of current anticancer immunotherapies.

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Version: author
Serval ID
serval:BIB_D59B3440A204
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Classification of current anticancer immunotherapies.
Journal
Oncotarget
Author(s)
Galluzzi L., Vacchelli E., Bravo-San Pedro J.M., Buqué A., Senovilla L., Baracco E.E., Bloy N., Castoldi F., Abastado J.P., Agostinis P., Apte R.N., Aranda F., Ayyoub M., Beckhove P., Blay J.Y., Bracci L., Caignard A., Castelli C., Cavallo F., Celis E., Cerundolo V., Clayton A., Colombo M.P., Coussens L., Dhodapkar M.V., Eggermont A.M., Fearon D.T., Fridman W.H., Fučíková J., Gabrilovich D.I., Galon J., Garg A., Ghiringhelli F., Giaccone G., Gilboa E., Gnjatic S., Hoos A., Hosmalin A., Jäger D., Kalinski P., Kärre K., Kepp O., Kiessling R., Kirkwood J.M., Klein E., Knuth A., Lewis C.E., Liblau R., Lotze M.T., Lugli E., Mach J.P., Mattei F., Mavilio D., Melero I., Melief C.J., Mittendorf E.A., Moretta L., Odunsi A., Okada H., Palucka A.K., Peter M.E., Pienta K.J., Porgador A., Prendergast G.C., Rabinovich G.A., Restifo N.P., Rizvi N., Sautès-Fridman C., Schreiber H., Seliger B., Shiku H., Silva-Santos B., Smyth M.J., Speiser D.E., Spisek R., Srivastava P.K., Talmadge J.E., Tartour E., Van Der Burg S.H., Van Den Eynde B.J., Vile R., Wagner H., Weber J.S., Whiteside T.L., Wolchok J.D., Zitvogel L., Zou W., Kroemer G.
ISSN
1949-2553 (Electronic)
ISSN-L
1949-2553
Publication state
Published
Issued date
2014
Volume
5
Number
24
Pages
12472-12508
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.
Keywords
adoptive cell transfer, checkpoint blockers, dendritic cell-based interventions, DNA-based vaccines, immunostimulatory cytokines, peptide-based vaccines, oncolytic viruses, Toll-like receptor agonists
Pubmed
Web of science
Create date
21/01/2015 11:30
Last modification date
20/08/2019 15:55
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