Synapse formation on neurons born in the adult hippocampus.

Details

Serval ID
serval:BIB_D584D388BEB6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Synapse formation on neurons born in the adult hippocampus.
Journal
Nature neuroscience
Author(s)
Toni N., Teng E.M., Bushong E.A., Aimone J.B., Zhao C., Consiglio A., van Praag H., Martone M.E., Ellisman M.H., Gage F.H.
ISSN
1097-6256
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
10
Number
6
Pages
727-734
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Although new and functional neurons are produced in the adult brain, little is known about how they integrate into mature networks. Here we explored the mechanisms of synaptogenesis on neurons born in the adult mouse hippocampus using confocal microscopy, electron microscopy and live imaging. We report that new neurons, similar to mature granule neurons, were contacted by axosomatic, axodendritic and axospinous synapses. Consistent with their putative role in synaptogenesis, dendritic filopodia were more abundant during the early stages of maturation and, when analyzed in three dimensions, the tips of all filopodia were found within 200 nm of preexisting boutons that already synapsed on other neurons. Furthermore, dendritic spines primarily synapsed on multiple-synapse boutons, suggesting that initial contacts were preferentially made with preexisting boutons already involved in a synapse. The connectivity of new neurons continued to change until at least 2 months, long after the formation of the first dendritic protrusions.
Keywords
Animals, Dendritic Spines/metabolism, Dendritic Spines/ultrastructure, Diagnostic Imaging/methods, Female, Hippocampus/cytology, Mice, Mice, Inbred C57BL, Microscopy, Confocal/methods, Microscopy, Electron, Transmission/methods, Models, Neurological, Neurons/cytology, Neurons/physiology, Organogenesis, Presynaptic Terminals, Synapses/physiology, Synapses/ultrastructure, Synaptic Transmission
Pubmed
Web of science
Create date
22/01/2010 7:47
Last modification date
20/08/2019 15:55
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