Preference for formulations containing calcium and vitamin D(3) in childhood: a randomized-sequence, open-label trial.

Details

Serval ID
serval:BIB_D56A4E0C6075
Type
Article: article from journal or magazin.
Collection
Publications
Title
Preference for formulations containing calcium and vitamin D(3) in childhood: a randomized-sequence, open-label trial.
Journal
Clinical therapeutics
Author(s)
Bianchetti A.A., Lava S.A., Bettinelli A., Rizzi M., Simonetti G.D., Bianchetti M.G.
ISSN
1879-114X (Electronic)
ISSN-L
0149-2918
Publication state
Published
Issued date
06/2010
Peer-reviewed
Oui
Volume
32
Number
6
Pages
1083-1087
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Children who experience adverse reactions to cow's milk or who have diseases predisposing them to low bone mass are often prescribed a supplementation of calcium and vitamin D(3), but adherence can be poor. Age-specific preferences for different formulations may exist and at least partially explain poor compliance.
The aim of this study was to compare the preference of Swiss children at risk for low bone mass for either a single-serving sachet or a suspension containing calcium and vitamin D(3).
Two different commercial formulations containing calcium and vitamin D(3), either as a lemon-flavored single-serving sachet or as a banana-flavored commercial suspension, were tested for preference by means of a 5-point facial hedonic scale in children aged 4 to 7 and 8 to 11 years. A concealed random allocation procedure was used. The investigator asking about preference was blinded to the sequence.
A total of 40 Swiss children (13 boys and 7 girls aged 4-7 years; 11 boys and 9 girls aged 811 years) were assessed in this study. Low bone mass risks included adverse reactions to cow's milk (n = 25); cerebral palsy (4), juvenile idiopathic arthritis (4), cystic fibrosis (3), inflammatory bowel diseases (2), anorexia nervosa (1), and osteogenesis imperfecta (1). Two children (10%) aged 4 to 7 years were not able to express their preference. Twelve of the remaining 18 children (67%) aged 4 to 7 years preferred the suspension, 5 (28%) did not express a clear preference, and 1 (5%) preferred the sachet (P < 0.002). In children aged 8 to 11 years, 15 (75%) preferred the sachet, 4 (20%) did not express a clear preference, and 1 (5%) preferred the suspension (P < 0.001). The results were not significantly different between boys and girls or between children initially presented the suspension and those initially presented the sachet.
In this small study, significantly more Swiss children aged 4 to 7 years who were prescribed a supplementation of calcium and vitamin D(3) preferred a banana-flavored suspension compared with those who preferred a lemon-flavored single-serving sachet. However, significantly more children aged 8 to 11 years prescribed the same supplementation preferred the single-serving sachet compared with the suspension.
Keywords
Adolescent, Bone Density, Calcium/administration & dosage, Chemistry, Pharmaceutical, Child, Cholecalciferol/administration & dosage, Dietary Supplements, Female, Humans, Male, Patient Preference, Switzerland
Pubmed
Web of science
Create date
08/03/2021 17:32
Last modification date
13/03/2021 7:26
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