Breath acetone as a marker of energy balance: an exploratory study in healthy humans.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D5692BE6E787
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Breath acetone as a marker of energy balance: an exploratory study in healthy humans.
Journal
Nutrition & diabetes
Author(s)
Bovey F., Cros J., Tuzson B., Seyssel K., Schneiter P., Emmenegger L., Tappy L.
ISSN
2044-4052 (Electronic)
ISSN-L
2044-4052
Publication state
Published
Issued date
10/09/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
50
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
An exploratory study was performed on eight healthy volunteers to assess how short-term changes in energy balance and dietary carbohydrate content impact breath acetone concentrations. Participants were studied on three occasions: on each occasion, they remained fasted and in resting conditions during the first 2 h to assess basal breath acetone and blood beta-hydroxybutyrate (BOHB). During the next 6 h, they remained fasted on one occasion (F), or were fed hourly high carbohydrate (HC) or low-carbohydrate (LC) meals to induce a positive energy balance on the other two occasions. They remained in resting conditions during 4 h, then performed a 2-hour low intensity exercise (25 W) inducing a negative energy balance. In resting conditions, breath acetone and blood BOHB concentrations increased progressively compared to basal values in F, but decreased and remained low throughout the test in HC. With LC, breath acetone increased progressively, while blood BOHB decreased. This exploratory study indicates that breath acetone reliably detects a stimulation of ketogenesis during a short-term fast. It also suggests that LC and HC differentially impact BOHB and acetone production and utilization, and reveals possible limitations to the use of breath acetone as a marker of energy balance.
Keywords
3-Hydroxybutyric Acid/blood, Acetone/analysis, Adult, Biomarkers/analysis, Biomarkers/blood, Breath Tests, Energy Metabolism/physiology, Exhalation/physiology, Female, Healthy Volunteers, Humans, Male, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2018 13:05
Last modification date
21/08/2019 6:10
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